Ozempic & Mounjaro Diarrhea: Causes and How to Support Your Body

Aug 5, 2025

Diarrhoea on Mounjaro, Ozempic or Wegovy? Why It Happens — and How to Support Your Body Naturally

If you're using a GLP-1 receptor agonist like Mounjaro® (tirzepatide), Ozempic® (semaglutide) or Wegovy®, chances are you’ve heard about the digestive side effects — including Ozempic Mounjaro diarrhea, which many people experience when starting treatment

Among the most common? Diarrhoea.

Though often mild and short-lived, some users report persistent or recurring episodes of diarrhoea after starting GLP-1 treatment. Understanding why this happens — and how it affects your body — is key to managing the side effect and avoiding long-term nutritional consequences.

Ozempic Mounjaro Diarrhea - Why Do GLP-1 Medications Cause It?

GLP-1 medications mimic the action of the body’s own glucagon-like peptide-1, a hormone that:

Slows gastric emptying
Reduces appetite
Enhances insulin secretion
Modulates gut motility

This slowed gastric emptying and altered digestion can disrupt the natural rhythm of the gastrointestinal system, leading to nausea, bloating, constipation — or, for many people, loose stools and diarrhoea.

Other contributing factors may include:

A sudden reduction in food volume or fibre
High-fat meals, which are more poorly tolerated
Changes in gut bacteria, influenced by altered digestion
Food moving too quickly through the intestines, reducing nutrient absorption

🧬 The Nutritional Impact of Diarrhoea

Diarrhoea isn’t just inconvenient — it can affect how well your body absorbs and retains vital nutrients, particularly when combined with reduced appetite, which is a central mechanism of GLP-1 medications.

Here’s what happens:

Electrolytes like magnesium, potassium and zinc are lost more rapidly
Water-soluble vitamins, including B-complex and vitamin C, are flushed out
Dehydration can impair energy, focus, and immune function
Fat-soluble vitamin absorption may drop if stools are too rapid or greasy

🧠 Symptoms of Nutrient Loss from Diarrhoea May Include:

Fatigue or low energy
Brain fog or poor concentration
Cramping or muscle weakness
Poor sleep quality
Weakened immunity
Changes in skin or hair health

This risk is magnified in those taking Ozempic, Mounjaro, or Wegovy, because they’re often eating less to begin with, which means nutrient reserves may already be lower.

🌿 How to Support Your Body If You’re Experiencing Diarrhoea

Here’s what can help:

1. Stay Hydrated — But Include Electrolytes

Water alone isn’t enough. Include sources of magnesium, potassium and sodium to replenish lost minerals.

2. Eat Small, Simple Meals

Stick to easy-to-digest foods: cooked veg, bananas, white rice, oats, root veg, plain crackers. Avoid greasy or very fibrous meals while symptoms persist.

3. Support Digestive Recovery With the Right Nutrients

Nutrient repletion is key — but not all supplements are created equal.

Look for a multivitamin that includes:

Magnesium bisglycinate or malate – gentle on digestion, supports muscle and nervous system
Zinc bisglycinate – essential for tissue repair and immune function
B-complex – needed to restore water-soluble vitamins lost in stools
Vitamin C – antioxidant support and iron absorption
Selenium and potassium – for thyroid, metabolism and electrolyte balance

💊 Nutritional Gaps on GLP-1 Medications Are Common

Whether or not you're experiencing digestive symptoms, GLP-1 treatments like Ozempic, Mounjaro and Wegovy can reduce overall nutrient intake simply by suppressing appetite and altering digestion.

Over time, this can lead to shortfalls in:

Iron
B-vitamins
Magnesium
Fat-soluble vitamins (A, D, E, K)
Zinc, selenium and other trace minerals

That’s why many users benefit from a high-quality, comprehensive multivitamin that’s designed to fill these gaps without irritating the gut.

✅ Why TRINITY Works for People on GLP-1 Injections

TRINITY by Arbor is a clean, three-phase multivitamin system designed to support your body’s natural rhythm — and to work especially well for those with lower food intake, sensitive digestion, or fluctuating energy.

Here’s what makes it ideal:

Key Ingredients for Digestive Support:

Magnesium bisglycinate & malate – in the morning and evening
Zinc bisglycinate – gentle on the stomach, highly absorbable
B-complex vitamins – full spectrum, methylated forms
Vitamin C – for antioxidant and gut support
Selenium, potassium iodide and molybdenum – to support detoxification and electrolyte balance

Why It’s Different:

🌱 No fillers, binders or bulkers — clean and gut-friendly
🕒 Timed delivery — nutrients spread across morning, day and night for better absorption
✅ Vegan-friendly and highly bioavailable

🧠 Summary

Diarrhoea is a common side effect of GLP-1 medications like Mounjaro, Ozempic and Wegovy
It may be mild or temporary, but it can lead to fluid and nutrient loss that affects energy, recovery, and gut health
Combined with reduced appetite, this can lead to deeper deficiencies over time
Supporting your body with hydration, a gentle diet, and smart nutrition can make a big difference
A high-quality multivitamin like TRINITY helps replenish what’s lost and protect against long-term shortfalls