🧬 MTHFR and Methylated Vitamins: What You Need to Know

If you’ve ever felt tired, foggy-headed, or struggled with mood despite taking a multivitamin, your body might not be absorbing certain nutrients as well as it could. One reason for this could be a variation in a gene called MTHFR.

Let’s break down what MTHFR means, why it matters, and how methylated vitamins can help.

🔍 What is the MTHFR gene?

MTHFR stands for methylenetetrahydrofolate reductase — an enzyme that plays a key role in processing folate (vitamin B9) into its active form, L-5-Methyl-THF.

Some people have MTHFR gene variations (polymorphisms) that make this conversion less efficient. This can lead to:

• Lower active folate levels

• Reduced methylation activity in the body

• Potential knock-on effects for B12 and other nutrients

⚠️ Why MTHFR variations can be a problem

Methylation is a vital biochemical process that impacts:

• Energy production

• Detoxification

• Mood regulation via neurotransmitter production

• DNA repair and synthesis

If your body struggles to methylate efficiently, you may experience:

• Fatigue

• Low mood or anxiety

• Poor concentration

• Higher homocysteine levels (linked to cardiovascular risk)

🌿 How methylated vitamins help

Methylated vitamins provide active, ready-to-use forms of nutrients — bypassing the need for the MTHFR enzyme to convert them.

Key examples include:

• L-5-Methyl-THF (methylated folate) – directly supports DNA synthesis, mood, and energy.

• Methylcobalamin (B12) – essential for nerve health, red blood cell formation, and brain function.

• Pyridoxal-5-Phosphate (B6) – supports neurotransmitter production and metabolism.

☀️ TRINITY: Designed for optimal methylation support

TRINITY by Arbor Vitamins contains multiple methylated forms across its morning and day formulas, including:

• L-5-Methyl-THF (folate) – in the morning formula for energy and mood support.

• Methylcobalamin (B12) – in the day formula to sustain brain function and energy.

• Pyridoxal-5-Phosphate (B6) – to support hormone regulation and neurotransmitters.

The 3-part daily system ensures nutrients are taken at the right time for absorption — and avoids clashes like calcium blocking iron.

Explore TRINITY here.

🛒 Where to buy methylated multivitamins

If you have an MTHFR variation (or simply want better nutrient absorption), look for a multivitamin that:

• Lists methylated forms like L-5-Methyl-THF and methylcobalamin on the label.

• Avoids fillers and binders that reduce bioavailability.

• Balances methylated nutrients with other synergistic vitamins and minerals.

TRINITY checks all of these boxes — and is available directly from Arbor Vitamins.

Shop here.

✅ The bottom line

An MTHFR variation doesn’t have to mean low energy, brain fog, or mood dips. Choosing a high-quality methylated multivitamin can help bypass conversion issues and ensure your body gets the nutrients it needs — in the form it can actually use.

Shop TRINITY today and experience the benefits of active-form nutrients and intelligent timing.

❓ FAQs: MTHFR and Methylated Vitamins

Q: How do I know if I have an MTHFR gene variation?
A: A simple genetic test can tell you. However, you don’t need a test to benefit from methylated vitamins — they work for everyone.

Q: Are methylated vitamins safe for daily use?
A: Yes, they’re the natural, active forms of nutrients your body already uses.

Q: Can methylated vitamins improve mood?
A: They can support mood by aiding neurotransmitter production, particularly if low folate or B12 is contributing to mood changes.

Q: Do I need a doctor’s prescription for methylated vitamins?
A: No, but consult your healthcare provider if you have specific medical concerns.