Best Supplements to Take with Lansoprazole (and Which Ones to Avoid)

Jul 9, 2026

Best Supplements to Take with Lansoprazole (and Which Ones to Avoid)

Quick Answer

Yes, you can usually take supplements safely while taking lansoprazole.

For most people, there's no need to avoid supplements simply because they've been prescribed lansoprazole. However, if you've been taking it for a prolonged period, it's sensible to review your nutritional intake. Like other proton pump inhibitors (PPIs), long-term lansoprazole treatment has been associated with reduced absorption of certain nutrients in some people, including vitamin B12, magnesium, iron and calcium.

The right supplements will depend on factors such as your diet, lifestyle, medical history and whether you've been advised that you have a vitamin or mineral deficiency. In many cases, a balanced diet may be all that's needed, while others may benefit from targeted supplementation.

In this guide, you'll discover:

Which supplements may be worth considering while taking lansoprazole.
Which supplements should be avoided or used with caution.
What to look for when choosing a high-quality supplement.
When it's worth seeking advice from your GP or pharmacist.

Pharmacist's Verdict

Question	Answer
Can I take supplements with lansoprazole?	✅ Yes, in most cases.
Should I take supplements just because I'm taking lansoprazole?	❌ Not necessarily.
Which nutrients are most commonly discussed?	✅ Vitamin B12, magnesium, iron and calcium.
Are there supplements I should avoid?	✅ Some should be used with caution depending on your circumstances.

Where Should You Start?

If you're taking lansoprazole long term, you don't need to buy lots of supplements. In most cases, it's better to focus on nutrients that are most commonly discussed during long-term PPI treatment rather than taking multiple products "just in case".

Supplement	When to consider it	Why?
High-quality multivitamin	If you're looking for general nutritional support	Can help support your overall intake of vitamins and minerals.
Magnesium	If your dietary intake is low or you've been advised your levels are reduced	Long-term PPI use has been associated with low magnesium levels in some people.
Vitamin B12	If you've been taking lansoprazole for several months or years	Reduced stomach acid may make vitamin B12 from food harder to absorb over time.
Iron	If you have iron deficiency or are at increased risk	Reduced stomach acid may affect iron absorption in some individuals.
Vitamin D	If you have limited sun exposure or are at risk of deficiency	Supports normal bones, muscles and immune function.

The next section looks at each of these in a little more detail and explains what to look for when choosing a supplement.

Supplements That May Be Worth Considering

Start with the Basics

Before buying several individual supplements, consider whether a high-quality multivitamin is all you need. For many people, it can provide comprehensive nutritional support without the complexity of taking multiple products.

(TRINITY is pharmacist formulated, uses bioavailable nutrient forms and separates nutrients across Morning, Day and Night formulations.)

Magnesium

Magnesium is one of the nutrients most commonly associated with long-term proton pump inhibitor (PPI) use. If you're choosing a magnesium supplement, opt for well-absorbed forms such as magnesium bisglycinate or magnesium taurate rather than magnesium oxide.

(Magnesium Complex contains magnesium bisglycinate and magnesium taurate with no magnesium oxide.)

Vitamin B12

If you've been taking lansoprazole for a prolonged period, vitamin B12 is worth keeping in mind. This is particularly relevant for older adults and those following vegetarian or vegan diets, who may already be at a greater risk of deficiency.

Probiotics

Some people choose to take probiotics alongside lansoprazole to support their gut microbiome. While they don't replace nutrients that may be affected by reduced stomach acid, they may be worth considering if you experience ongoing digestive symptoms.

Vitamin D

If you spend little time outdoors or have previously been found to have low vitamin D levels, supplementation may be appropriate. Vitamin D contributes to the maintenance of normal bones, normal muscle function and the normal function of the immune system.

Supplements to Avoid (or Use with Caution)

Most supplements can be taken safely with lansoprazole. The bigger risk is often taking supplements you don't need or combining products that contain the same nutrients.

Supplement	Recommendation	Why?
Iron	⚠️ Only supplement if advised	Iron should generally only be taken if you have a confirmed deficiency or a healthcare professional has recommended it.
High-dose vitamins and minerals	⚠️ Avoid unless clinically appropriate	Taking more than the recommended amount isn't necessarily more beneficial and may increase the risk of unwanted effects.
Multiple multivitamins	⚠️ Avoid	Taking more than one multivitamin can lead to unnecessary duplication of certain nutrients.
St John's wort	⚠️ Use with caution	St John's wort can interact with many prescription medicines and should only be taken after seeking professional advice.

If you're thinking about adding more than one supplement to your routine, take a moment to check the ingredients. Many products contain the same vitamins and minerals, making it easy to double up without realising.

When in doubt, speak to your GP or pharmacist before starting a new supplement, particularly if you take other prescription medicines or have a long-term health condition.

When Is It Worth Seeking Advice?

Most people taking lansoprazole won't need to make major changes to their supplement routine. However, it's worth speaking to your GP or pharmacist if:

You've been taking lansoprazole for several months or years and are concerned about your nutritional intake.
You have symptoms that could suggest a vitamin or mineral deficiency, such as persistent tiredness, muscle weakness or pins and needles.
You're planning to take several supplements at the same time.
You have kidney disease or another long-term medical condition.
You're pregnant or breastfeeding.
You're taking multiple prescription medicines.

Your healthcare professional can help you decide whether dietary changes, blood tests or targeted supplementation are appropriate, helping you avoid spending money on supplements you may not actually need.

Frequently Asked Questions

Can I take supplements with lansoprazole?

Yes. Most supplements can be taken safely alongside lansoprazole. If you have a long-term medical condition or take several prescription medicines, it's always sensible to check with your GP or pharmacist before starting a new supplement.

What are the best supplements to take with lansoprazole?

A high-quality multivitamin is often the best place to start. Depending on your individual needs, magnesium, vitamin B12, vitamin D or iron may also be appropriate.

Does lansoprazole affect vitamin absorption?

Long-term lansoprazole treatment has been associated with reduced absorption of certain nutrients in some people, particularly vitamin B12, magnesium, iron and calcium.

Can I take magnesium with lansoprazole?

Yes. Magnesium supplements can generally be taken safely with lansoprazole. If you're choosing a supplement, look for well-absorbed forms such as magnesium bisglycinate or magnesium taurate.

Can I take probiotics with lansoprazole?

Yes. Probiotics don't interact with lansoprazole and some people choose to take them to support their gut microbiome. However, they're not a replacement for a balanced diet or nutrients that may be affected by long-term PPI use.

Should I take vitamin B12 while taking lansoprazole?

Not everyone needs to. However, if you've been taking lansoprazole for a prolonged period or are at increased risk of vitamin B12 deficiency, it's worth discussing supplementation with your GP or pharmacist.

Can I take vitamin D with lansoprazole?

Yes. Vitamin D can generally be taken safely with lansoprazole and may be appropriate if you have low vitamin D levels or are at increased risk of deficiency.

Should I avoid any supplements while taking lansoprazole?

Most supplements can be taken safely. The main exception is avoiding unnecessary or duplicate supplementation, particularly if you're already taking a multivitamin or other products containing the same nutrients.

Should I stop taking lansoprazole if I'm worried about vitamin deficiencies?

No. Continue taking lansoprazole exactly as prescribed. If you're concerned about your nutritional intake or think you may have developed a deficiency, speak to your GP or pharmacist before making any changes to your medication.

References

British National Formulary (BNF). Lansoprazole.
National Institute for Health and Care Excellence (NICE). Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management.
NHS. Lansoprazole.
Heidelbaugh JJ. Proton Pump Inhibitors and Risk of Vitamin and Mineral Deficiency: Evidence and Clinical Implications. Therapeutic Advances in Drug Safety.
Freedberg DE, Kim LS, Yang YX. The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice. Gastroenterology.
European Food Safety Authority (EFSA). Authorised Health Claims for Vitamins and Minerals.