Getting Headaches on Mounjaro or Ozempic? What Causes Them & How Nutrition Can Help

Aug 5, 2025

Headaches on Mounjaro or Ozempic? Here's What Could Be Causing Them — and How to Support Your Body

GLP-1 medications like Mounjaro®, Ozempic®, and Wegovy® are highly effective for weight loss and metabolic support. But for some users, especially in the early weeks of treatment, they come with an unexpected and frustrating side effect: frequent headaches.

If you’ve recently started on one of these injections and are noticing tension, pressure, or migraines creeping in — you’re not alone. Fortunately, there are clear reasons why this might be happening — and steps you can take to support your body naturally.

Why Do GLP-1 Medications Cause Headaches?

While not guaranteed, headaches are a known side effect of GLP-1 receptor agonists — often most noticeable in the first 4–8 weeks. There are a few possible reasons:

1. Dehydration and fluid loss

GLP-1s can cause mild dehydration through reduced thirst, lower food volume, and side effects like nausea or diarrhoea. Even a small dip in fluid or electrolyte levels can trigger headaches, dizziness and tension.

2. Blood sugar shifts

As your food intake drops, your blood sugar may fluctuate more — particularly if you’re not eating regularly. These ups and downs can lead to low-grade or reactive headaches.

3. Nutrient deficiencies

Reduced appetite means fewer meals — and that can lead to shortfalls in magnesium, B2 (riboflavin), B6 and sodium. These nutrients help regulate nerve signalling, blood flow, and pain sensitivity.

4. Hormonal and metabolic adjustment

As your body adapts to the medication, it may release or suppress certain hormones that affect cerebral blood vessels and inflammation — leading to temporary headache symptoms.

🧬 Nutrients That Help Support Headache Prevention

Certain vitamins and minerals have been shown to support the body’s ability to manage and reduce headache frequency — especially when taken consistently.

Nutrient	Role in Headache Support	GLP-1 Risk Factor
Magnesium	Calms nerves, regulates muscle tension and vasodilation	Lost via diarrhoea, low intake
Vitamin B2 (Riboflavin)	Supports energy metabolism in brain cells	Depleted with low protein/fat intake
Vitamin B6	Involved in neurotransmitter regulation	Low intake may alter serotonin balance
Folate & B12	Help reduce homocysteine, support oxygen flow	Often under-consumed on calorie restriction
Potassium & Sodium	Maintain fluid balance, prevent tension	Electrolyte shifts may contribute

💊 Nutritional Gaps Are Common on GLP-1s

It’s important to remember: GLP-1 medications reduce appetite and often total food intake — which makes nutritional gaps much more likely, especially for water-soluble vitamins and minerals.

These deficiencies may not just contribute to headaches, but also:

Fatigue
Sleep disruption
Muscle cramps
Mood changes
Brain fog

Supporting your system with a well-formulated multivitamin can help address the root causes behind these side effects — and reduce their frequency over time.

🌿 How TRINITY Helps Support Headache-Prone GLP-1 Users

TRINITY by Arbor Vitamins is a clean, three-phase multivitamin designed to support your energy, nervous system, hydration, and overall wellbeing — all things impacted by headaches.

☀️ Morning Formula:

Vitamin B2 (Riboflavin-5-Phosphate) – active form shown to help reduce migraine frequency
Magnesium malate – energising and supportive for muscle tension
Vitamin B1, B5, Folate, Biotin – for metabolic and neurological function
Iron + Vitamin C – for oxygen delivery and fatigue support

🌞 Day Formula:

Vitamin B6 (P5P) + B12 (Methylcobalamin) – helps regulate neurotransmitters
Potassium Iodide – supports hydration and nerve signalling
Chromium, K2 and antioxidants – protect vascular health

🌙 Night Formula:

Magnesium bisglycinate – calming and easily absorbed, ideal for bedtime
Zinc & selenium – support repair, inflammation control, and hormonal balance
B3 (niacinamide) – may improve sleep and reduce tension

✅ Why TRINITY Works:

Bioavailable, active nutrient forms
Gentle on digestion — no fillers, binders or harsh additives
Dosed across morning, day and night to maximise absorption and avoid clashes
Especially effective for people with low appetite, digestive sensitivity, or fatigue

Shop TRINITY here.

🧠 Summary

Headaches are a common side effect for people starting Mounjaro, Ozempic or Wegovy — often caused by dehydration, electrolyte loss or nutrient depletion
Nutrients like magnesium, B2, and B6 play a key role in supporting nerve health and circulation
A comprehensive, gut-friendly multivitamin like TRINITY helps fill gaps, support blood flow, and reduce strain on your system — naturally