Fat-Soluble Vitamins on Ozempic & Mounjaro | Why You May Be Missing Key Nutrients

Jul 21, 2025

Fat-Soluble Vitamins on Ozempic: What You’re Likely Missing

If you’re taking a GLP-1 medication like Ozempic®, Mounjaro®, or Wegovy®, chances are your focus is on weight loss, appetite control, or managing blood sugar. But there’s a less obvious concern that could have long-term effects: fat-soluble vitamin deficiencies.

These essential nutrients — vitamins A (as beta-carotene), D, E, and K — are absorbed differently from water-soluble ones like vitamin C or B-complex. And unfortunately, GLP-1 medications can make it harder to get and absorb enough of them.

🧬 What Are Fat-Soluble Vitamins?

Fat-soluble vitamins require dietary fat and proper digestion to be absorbed and used by the body. Unlike water-soluble vitamins, they are stored in fatty tissue and the liver, meaning both deficiencies and toxicities can develop over time — often silently.

Here’s what each one does:

Vitamin A (as beta-carotene): Essential for vision, skin health, and immunity
Vitamin D3: Regulates calcium, supports bone health, and plays a critical role in immune and mood balance
Vitamin E: A powerful antioxidant that protects cells from oxidative stress
Vitamin K2 (MK-7): Directs calcium into bones and teeth, and away from arteries

🚫 Why GLP-1 Users Are at Risk of Deficiency

GLP-1 medications change how your body processes food in several ways — all of which impact the absorption of fat-soluble vitamins:

1. Reduced Appetite = Less Dietary Fat

Many GLP-1 users eat far less fat overall, whether intentionally or simply due to early satiety. Less fat means less absorption of fat-soluble vitamins, even if they’re present in food or supplements.

2. Delayed Gastric Emptying

GLP-1s slow how quickly your stomach empties, which can interfere with digestion and nutrient uptake — particularly for fat-based nutrients that require bile flow and enzyme activity.

3. Digestive Side Effects

Nausea, diarrhoea, or reduced meal frequency can limit both nutrient intake and absorption surface area in the gut, compounding the issue.

🩺 Why These Deficiencies Matter

A shortfall in fat-soluble vitamins may not cause symptoms right away — but over time, it can contribute to:

Weakened immune response
Low mood and fatigue
Increased inflammation
Bone density loss
Poor skin and eye health

For those actively losing weight or managing insulin resistance, this is especially concerning.

TRINITY: Multivitamin Support That Includes Every Fat-Soluble Vitamin

While many generic multivitamins only include one or two fat-soluble vitamins — and often in poor forms — TRINITY includes all four in their most bioavailable formats, spread across the day for optimal absorption and synergy.

Here’s how TRINITY helps fill the gap:

✅ What You Get in TRINITY

Vitamin D3 (cholecalciferol) – included in the Day formula for mood, bone, and immune support
Vitamin K2 (MK-7) – paired with D3 to aid calcium regulation
Vitamin E (d-alpha tocopherol) – included in the Night formula for overnight cellular protection
Beta-Carotene – a safe, plant-based precursor to vitamin A, included in the Night formula

💡 These are active forms, in gentle, vegan-friendly capsules — with no synthetic additives or fillers.

🕒 Timing for Better Uptake

TRINITY’s three-phase system ensures that fat-soluble vitamins are distributed throughout the day, improving absorption by reducing competition and allowing them to pair naturally with other co-factors like magnesium, zinc, and healthy fats from food.

This is especially useful for GLP-1 users, whose meals may be small or irregular.

🧪 Summary: Don’t Overlook the Essentials

Fat-soluble vitamins may be harder to absorb on medications like Ozempic and Mounjaro — but they’re also some of the most essential for long-term health. A multivitamin that includes them all, in the right forms and timing, can make a major difference.

TRINITY was designed with this in mind — to deliver the nutrients your body needs, in a clean, supportive format that actually works with your digestion, not against it.

✅ Key Takeaways

GLP-1 meds can reduce fat-soluble vitamin absorption due to appetite suppression and digestive changes
Vitamins A (beta-carotene), D3, E, and K2 are critical for immunity, mood, and bone health
TRINITY includes all four, in active forms, spaced throughout the day for better absorption and impact