Should You Take a Multivitamin While on Retatrutide?

Retatrutide significantly reduces appetite.

For many people, that means:

• Smaller meals

• Fewer snacks

• Lower calorie intake

• Reduced dietary variety

So a common question arises:

Should you take a multivitamin while using retatrutide?

The answer depends on your overall intake — but appetite suppression changes the nutritional equation.

Retatrutide Doesn’t “Deplete” Nutrients

Retatrutide does not directly remove vitamins or minerals from the body.

However, sustained calorie reduction can reduce:

• Protein intake

• Iron exposure

• Zinc intake

• Magnesium intake

• B vitamin intake

• Fat-soluble vitamin absorption (if dietary fat drops)

For a deeper dive into common gaps, see:
Nutrient Deficiencies on Retatrutide: What You Need to Watch

Appetite Suppression and Dietary Density

When appetite is strong, nutritional adequacy often happens naturally through food volume.

When appetite drops significantly, nutritional density becomes more important.

For example:

• A smaller meal must now provide adequate protein and micronutrients

• Reduced red meat intake may affect iron exposure

• Lower dietary fat may influence vitamin D absorption

Related reading:
Retatrutide and Micronutrient Absorption: Does Slower Digestion Matter?

Who May Benefit from a Multivitamin?

A multivitamin may be worth considering if:

• Total calorie intake has dropped significantly

• Weight loss is rapid

• Protein intake is inconsistent

• Dietary variety has narrowed

• Fatigue or hair shedding is occurring

See also:
Fatigue on Retatrutide: Causes and How to Support Energy
Hair Loss on Retatrutide: Is It a Nutrient Issue?

Are All Multivitamins Equal?

Not necessarily.

Several factors influence multivitamin effectiveness:

• Nutrient forms (e.g. oxide vs chelated minerals)

• Dose adequacy

• Mineral competition (iron vs calcium, zinc vs copper)

• Fat-soluble vitamin timing

• Digestive tolerance

Understanding nutrient interaction can be helpful:
Does Splitting Supplements Improve Absorption?
How Do We Absorb Vitamins and Minerals?

Timing Considerations on Retatrutide

Because retatrutide slows gastric emptying, digestive timing may become more relevant.

Some considerations include:

• Iron absorbs best away from calcium

• Fat-soluble vitamins absorb better with dietary fat

• Magnesium may be better tolerated later in the day

• B vitamins are often energising earlier in the day

Learn more:
Morning vs Evening Supplements: Maximising Nutrient Absorption

Food First — But Structure Matters

Whole foods remain the foundation of nutritional adequacy.

However, when appetite is significantly suppressed, achieving optimal micronutrient intake from food alone may become more challenging.

This is especially relevant during:

• Rapid weight loss

• Aggressive calorie deficits

• Reduced dietary diversity

When to Seek Testing

If symptoms such as:

• Persistent fatigue

• Hair thinning

• Dizziness

• Muscle weakness

• Poor recovery

are present, laboratory testing may help assess:

• Iron levels

• B12 status

• Vitamin D

• Electrolytes

FAQ: Multivitamins on Retatrutide

Does retatrutide require a multivitamin?

Not automatically, but reduced calorie intake may increase the risk of nutrient gaps.

Can appetite suppression affect vitamin intake?

Yes. Smaller meals may reduce micronutrient exposure over time.

Should I take iron separately?

Iron competes with certain minerals for absorption; timing may matter.

Do fat-soluble vitamins need dietary fat?

Yes. Vitamins A, D, E and K absorb best alongside fat.

Is food alone enough during rapid weight loss?

It depends on dietary variety, protein intake and calorie levels.

Final Thoughts

Retatrutide changes appetite — and appetite shapes intake.

While the medication does not directly deplete nutrients, sustained calorie reduction can influence micronutrient exposure and protein adequacy.

For some individuals, structured supplementation may provide nutritional stability during prolonged appetite suppression.

Understanding nutrient timing and interaction becomes increasingly important when meal volume decreases.