Fatigue on Ozempic, Mounjaro or Wegovy? Common Causes & How to Support Energy Levels

Jul 28, 2025

Fatigue on Ozempic or Mounjaro? Here’s Why It Happens – and What Can Help

GLP-1 medications like Ozempic, Mounjaro, and Wegovy can be transformative for weight management — but for many users, a troubling side effect emerges: persistent fatigue.

This isn’t just anecdotal. Across Reddit forums, clinical trials, and patient reports in the UK, many people describe a “low energy slump” within the first few weeks or months of taking these injections.

Let’s look at why this happens, which nutrients are commonly depleted, and how the right multivitamin – like TRINITY – can help support energy when food intake drops.

🧠 Why GLP-1 Medications Can Cause Fatigue

1. Reduced food = reduced fuel

Ozempic and Mounjaro suppress appetite by mimicking a hormone (GLP-1) that slows digestion and promotes satiety. This leads to lower calorie and carbohydrate intake, which in turn reduces energy production – especially if you’re skipping meals.

2. Lower intake of B vitamins and iron

These are the core drivers of cellular energy (mitochondrial ATP production). Without them, even with enough calories, your body may not be converting them effectively into energy.

3. Electrolyte shifts

GLP-1 medications can cause subtle fluid and mineral imbalances, especially if nausea or diarrhoea are present. This impacts magnesium and potassium levels, which are crucial for energy metabolism and nerve function.

4. Impaired fat absorption

Fat-soluble vitamins like A, D, E, and K are often under-absorbed on a low-fat diet or when food intake is inconsistent — compromising hormonal and metabolic health.

🧪 Key Nutrients That Support Energy (And Are Often Lacking)

Nutrient	Why It Matters for Energy	Risk When Taking GLP-1s
B1, B2, B3, B5, B6, B12, Folate	Energy metabolism, cognitive function	Lower intake = mitochondrial slowdown
Iron	Red blood cell production, oxygen delivery	Skipping meals = missed iron sources
Magnesium	Energy production, sleep, mood	Nausea & diarrhoea can reduce levels
Vitamin C	Iron absorption, adrenal support	Less fruit/veg intake = lower C
Vitamin D & K2	Mitochondrial and muscle health	Fat malabsorption affects uptake

🌿 How TRINITY Helps Fight Fatigue While on Ozempic or Mounjaro

TRINITY by Arbor Vitamins was designed specifically to support energy, sleep, hormone function and immune health — all of which are impacted by appetite suppression and GLP-1 side effects.

☀️ Morning Formula Highlights:

Full B-Complex (B1, B2, B5, Folate, Biotin) – Supports daily energy from the first dose
Iron (bisglycinate) + Vitamin C – High absorption, non-constipating form to support red blood cell function
Magnesium malate – Boosts ATP (energy) production and muscle function

🌞 Day Formula:

Vitamin B6 (P5P) + B12 (Methylcobalamin) – Active forms for sustained energy and neurological balance
Vitamin D3 + K2 – Supports mitochondrial energy and bone-muscle coordination

🌙 Night Formula:

Magnesium bisglycinate – Calming, well-tolerated form to support sleep and recovery
Zinc, Selenium – Supports thyroid health and energy regulation overnight

🧬 Clean, Bioavailable & Time-Optimised

TRINITY avoids harsh fillers or poorly absorbed forms of nutrients. Its three-stage design follows your body’s natural rhythm — delivering the right nutrients at the right time.

Morning = metabolism boost
Day = sustained energy & hormone support
Night = calming, restorative blend for recovery

✅ Summary

Fatigue on Ozempic or Mounjaro is very common, especially in the first 6–12 weeks
Causes include lower calorie and nutrient intake, disrupted digestion, and depleted electrolytes
TRINITY provides targeted support for energy, using well-absorbed, time-optimised ingredients designed to replenish what your diet may lack